Mairang Presbyterian Science College is a rural institution of higher learning located in Mairang, within the Eastern West Khasi Hills District of Meghalaya. The College holds the distinction of being the first Science College in the district, dedicated to the teaching of Science and Mathematics.

The College is situated in Mairang town, the District Headquarter of Eastern West Khasi District. Mairang holds historical importance as the traditional headquarters of Hima Nongkhlaw, the kingdom once ruled by U Tirot Sing, the great Khasi patriot, ruler, and one of the foremost freedom fighters of Northeast India. He led a strong resistance against British colonial forces and died in 1835 as a prisoner in Dhaka, Bangladesh. The town also serves as the headquarters of the Mairang Presbytery, a constituent unit of the Khasi Jaintia Synod Sepngi under the Presbyterian Church of India.

The College is a co-educational institution, established by the Mairang Presbytery during the academic session 2006–2007, and is registered under the Meghalaya Societies Registration Act (7 of 1990) with Registration No. NRS/MPC-843/2004, dated 19th March 2004, through the Office of the Joint Registrar of Societies, West Khasi Hills, Nongstoin.

In a significant academic expansion, the College formally introduced the Arts stream on 30th November 2023, thereby extending its educational scope. With this development, Mairang Presbyterian Science College now offers academic programs in both Science and Arts, reinforcing its commitment to providing holistic, value-based education in a historically rich and intellectually stimulating environment.