Mairang Presbyterian Science College is a purely private College established during 2006-07 by Mairang Presbytery the Sponsoring Body. Mairang Presbytery is a constituent unit of Khasi Jaintia Presbyterian Synod Sepngi. The College started functioning with the opening of the First Year B.Sc (Pass Course) in June, 2007 during the academic session 2007-08. At that time the College functions at its temporary campus located near Mot Tirot Sing in Mairang Mission and it is housed in a three-storeyed RCC building owned by Mairang Presbytery.

With the completion of the first phase of Construction of the College Building at its Permanent Campus, all the Departments except the office were shifted to the New Campus.

Chronological Events of the College

1. 1.6^th June 2006 is the Red Letter Day for the College since on this day the College was inaugurated by the Sponsoring Body i.e., Mairang Presbytery to serve the people of Mairang and its adjoining areas and West Khasi Hills District at large. 

2. 2. The year 2009 is a memorable year for our College as it witnessed the opening of the Higher Secondary Section in Science Stream. 

3. 3.The year 2011 saw the College crossing another milestone as the Foundation Stone for the construction of the College Building in its Permanent Campus was laid by Prof. R.C Laloo, Education Minister, Government of Meghalaya on 7^th May, 2011. 

4. 4. In 2011 the College also witnessed a breakthrough in the academic development when the First Batch of B.Sc (Pass Course) graduated from NEHU and First Batch of Class XII passed the HSSLC Examination from MBOSE. 

5. 5. The year 2013 is a momentous year where the College took a giant leap from its Temporary Campus to its Permanent Campus. The College Building was inaugurated on the 6^th September, 2013 by Dr. Mukul Sangma, Honourable CM, Govt. of Meghalaya. 

6. 6. The year 2015 took the College to another level of development when the North Eastern Hill University implemented the Semester System which automatically upgraded the College to its Honours Course. 

7. 7. The year 2017 is another memorable year for the College as in this year the College attains the tenth milestone in its journey to provide Higher Education in Science and Mathematics to Mairang and its adjoining areas and West Khasi Hills District at large. 

8. 8. The year 2018 is another year of achievement for the College as the First Batch of B.Sc Honours students came out with flying colours in the B.Sc. VI Semester Examination conducted by North Eastern Hill University with 100% pass percentage. 

9. 9. The College witnessed another level of development when the Higher Secondary Section was delinked and shifted to its own building on the 30^th September, 2019.